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A cost-effective and sustainable healthcare information system relies on the ability to collect, process, and transform healthcare data into information, knowledge, and action. However, in implementing such systems, healthcare providers face many complex and unique challenges. This article proposes a systematic framework for conceptualizing data-driven and mobile- and cloud-enabled smart healthcare systems. With adoption of smart healthcare systems, healthcare organizations can provide cost-effective quality healthcare services with less IT set-up costs and reduced risk.