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Cellular delivery of drugs and biomolecules (eg proteins and siRNA) is a central issue in biomedicine.[1] Promising delivery vehicles based on nanoparticles have been investigated as vectors.[2] Gold nanoparticles (AuNPs) are promising candidates for cellular delivery due to their low toxicity, biocompatibility and tunable surface functionalities.[3] Many studies have been carried out to understand the cellular uptake of AuNPs and the physico-chemical properties, such as size,[4] shape,[4a, 5] and surface chemistry,[5–6] that influence uptake. For example, Chan et al.[4a] have demonstrated the size dependence of cellular uptake, and our group has shown the role of surface charge and hydrophobicity on uptake.[6a] Tailoring the size and surface chemistry of AuNPs provides structural diversity,[7] allowing direct control