Authors
Brian W Kunkle, Benjamin Grenier-Boley, Rebecca Sims, Joshua C Bis, Vincent Damotte, Adam C Naj, Anne Boland, Maria Vronskaya, Sven J Van Der Lee, Alexandre Amlie-Wolf, Céline Bellenguez, Aura Frizatti, Vincent Chouraki, Eden R Martin, Kristel Sleegers, Nandini Badarinarayan, Johanna Jakobsdottir, Kara L Hamilton-Nelson, Sonia Moreno-Grau, Robert Olaso, Rachel Raybould, Yuning Chen, Amanda B Kuzma, Mikko Hiltunen, Taniesha Morgan, Shahzad Ahmad, Badri N Vardarajan, Jacques Epelbaum, Per Hoffmann, Merce Boada, Gary W Beecham, Jean-Guillaume Garnier, Denise Harold, Annette L Fitzpatrick, Otto Valladares, Marie-Laure Moutet, Amy Gerrish, Albert V Smith, Liming Qu, Delphine Bacq, Nicola Denning, Xueqiu Jian, Yi Zhao, Maria Del Zompo, Nick C Fox, Seung-Hoan Choi, Ignacio Mateo, Joseph T Hughes, Hieab H Adams, John Malamon, Florentino Sanchez-Garcia, Yogen Patel, Jennifer A Brody, Beth A Dombroski, Maria Candida Deniz Naranjo, Makrina Daniilidou, Gudny Eiriksdottir, Shubhabrata Mukherjee, David Wallon, James Uphill, Thor Aspelund, Laura B Cantwell, Fabienne Garzia, Daniela Galimberti, Edith Hofer, Mariusz Butkiewicz, Bertrand Fin, Elio Scarpini, Chloe Sarnowski, Will S Bush, Stéphane Meslage, Johannes Kornhuber, Charles C White, Yuenjoo Song, Robert C Barber, Sebastiaan Engelborghs, Sabrina Sordon, Dina Voijnovic, Perrie M Adams, Rik Vandenberghe, Manuel Mayhaus, L Adrienne Cupples, Marilyn S Albert, Peter P De Deyn, Wei Gu, Jayanadra J Himali, Duane Beekly, Alessio Squassina, Annette M Hartmann, Adelina Orellana, Deborah Blacker, Eloy Rodriguez-Rodriguez, Simon Lovestone, Melissa E Garcia, Rachelle S Doody, Carmen Munoz-Fernadez, Rebecca Sussams, Honghuang Lin, Thomas J Fairchild, Yolanda A Benito, Clive Holmes, Hata Karamujić-Čomić, Matthew P Frosch, Hakan Thonberg, Wolfgang Maier, Gennady Roshchupkin, Bernardino Ghetti, Vilmantas Giedraitis, Amit Kawalia, Shuo Li, Ryan M Huebinger, Lena Kilander, Susanne Moebus, Isabel Hernández, M Ilyas Kamboh, RoseMarie Brundin, James Turton, Qiong Yang, Mindy J Katz, Letizia Concari, Jenny Lord, Alexa S Beiser, C Dirk Keene, Seppo Helisalmi, Iwona Kloszewska, Walter A Kukull, Anne Maria Koivisto, Aoibhinn Lynch, Lluís Tarraga, Eric B Larson, Annakaisa Haapasalo, Brian Lawlor, Thomas H Mosley, Richard B Lipton, Vincenzo Solfrizzi, Michael Gill, WT Longstreth Jr, Thomas J Montine, Vincenza Frisardi, Monica Diez-Fairen, Fernando Rivadeneira, Ronald C Petersen, Vincent Deramecourt, Ignacio Alvarez, Francesca Salani, Antonio Ciaramella, Eric Boerwinkle, Eric M Reiman, Nathalie Fievet, Jerome I Rotter
Publication date
2019/3
Journal
Nature genetics
Volume
51
Issue
3
Pages
414-430
Publisher
Nature Publishing Group US
Description
Risk for late-onset Alzheimer’s disease (LOAD), the most prevalent dementia, is partially driven by genetics. To identify LOAD risk loci, we performed a large genome-wide association meta-analysis of clinically diagnosed LOAD (94,437 individuals). We confirm 20 previous LOAD risk loci and identify five new genome-wide loci (IQCK, ACE, ADAM10, ADAMTS1, and WWOX), two of which (ADAM10, ACE) were identified in a recent genome-wide association (GWAS)-by-familial-proxy of Alzheimer’s or dementia. Fine-mapping of the human leukocyte antigen (HLA) region confirms the neurological and immune-mediated disease haplotype HLA-DR15 as a risk factor for LOAD. Pathway analysis implicates immunity, lipid metabolism, tau binding proteins, and amyloid precursor protein (APP) metabolism, showing that genetic variants affecting APP and Aβ processing are associated not only with early-onset autosomal …
Scholar articles
BW Kunkle, B Grenier-Boley, R Sims, JC Bis… - Nature genetics, 2019
BW Kunkle, B Grenier-Boley, R Sims, JC Bis… - Nature Genetics, 2019
BW Kunkle, B Grenier-Boley, R Sims, JC Bis… - Nature genetics, 2019
