Authors
University of Utah Weiss Robert B. 14 Dunn Diane M. 14, NISC Comparative Sequencing Program, NHGRI Green Eric D. 15 Blakesley Robert W. 15 Bouffard Gerard G. 15, Pieter J de Jong, Kazutoyo Osoegawa, Baoli Zhu, Marco Marra, Jacqueline Schein, Ian Bosdet, Chris Fjell, Steven Jones, Martin Krzywinski, Carrie Mathewson, Asim Siddiqui, Natasja Wye, Genome Sequencing Center, Washington University School of Medicine McPherson John 1 17, Shaying Zhao, Claire M Fraser, Jyoti Shetty, Sofiya Shatsman, Keita Geer, Yixin Chen, Sofyia Abramzon, William C Nierman, Richard A Gibbs, George M Weinstock, Paul H Havlak, Rui Chen, K James Durbin, Rain Simons, Yanru Ren, Xing-Zhi Song, Bingshan Li, Yue Liu, Xiang Qin, Simon Cawley, Case Western Reserve University Bailey Jeffrey A. 4 Eichler Evan E. 4 Tuzun Eray 4, EBI, Wellcome Trust Genome Campus Birney Ewan 21 Mongin Emmanuel 21 Ureta-Vidal Abel 21 Woodwark Cara 21, EMBL, Heidelberg Zdobnov Evgeny 22 Bork Peer 22 23 Suyama Mikita 22 Torrents David 22, Fraunhofer-Chalmers Research Centre for Industrial Mathematics, Gothenburg Alexandersson Marina 24, Fred Hutchinson Cancer Research Center Trask Barbara J. 25 Young Janet M. 25, Genome Therapeutics Smith Douglas 12 13 Huang Hui 12 Fechtel Kim 12 Wang Huajun 12 Xing Heming 12 Weinstock Keith 12, Incyte Corporation Daniels Sue 26 Gietzen Darryl 26 Schmidt Jeanette 26 Stevens Kristian 26 Vitt Ursula 26 Wingrove Jim 26, Institut Municipal d'Investigacio Medica, Barcelona> Camara Francisco 27 Mar Albà M. 27 Abril Josep F. 27 Guigo Roderic 27, Institute for Systems Biology Smit Arian 28, Lawrence Berkeley National Laboratory Dubchak Inna 29 30 Rubin Edward M. 29 30 Couronne Olivier 29 30 Poliakov Alexander 29, Max Delbrück Center for Molecular Medicine Hübner Norbert 23 Ganten Detlev 23 Goesele Claudia 23 31 Hummel Oliver 23 31 Kreitler Thomas 23 31 Lee Young-Ae 23 Monti Jan 23 Schulz Herbert 23 Zimdahl Heike 23, Max Planck Institute for Molecular Genetics, Berlin Himmelbauer Heinz 31 Lehrach Hans 31, Medical College of Wisconsin Jacob (Principal Investigator) Howard J. 32 Bromberg Susan 33 Gullings-Handley Jo 32 Jensen-Seaman Michael I. 32 Kwitek Anne E. 32 Lazar Jozef 32 Pasko Dean 33 Tonellato Peter J. 32 Twigger Simon 32, MRC Functional Genetics Unit, University of Oxford Ponting Chris P. 34 Duarte Jose M. 34 Rice Stephen 34 Goodstadt Leo 34 Beatson Scott A. 34 Emes Richard D. 34 Winter Eitan E. 34 Webber Caleb 34, MWG-Biotech Brandt Petra 35 Nyakatura Gerald 35, Roche Genetics and Roche Center for Medical Genomics Lindpaintner Klaus 37, Sanger Institute Andrews T. Dan 38 Caccamo Mario 38 Clamp Michele 38 Clarke Laura 38 Curwen Valerie 38 Durbin Richard 38 Eyras Eduardo 38 Searle Stephen M. 38, Stanford University Cooper Gregory M. 39 Batzoglou Serafim 40 Brudno Michael 40 Sidow Arend 39 Stone Eric A. 39, Center for the Advancement of Genomics Craig Venter J. 3 8, University of Arizona Payseur Bret A. 41, Université de Montréal Bourque Guillaume 42, Universidad de Oviedo López-Otín Carlos 43 Puente Xose S. 43, University of California, Berkeley Chakrabarti Kushal 44 Chatterji Sourav 44 Dewey Colin 44 Pachter Lior 45 Bray Nicolas 45 Yap Von Bing 45 Caspi Anat 46, University of California, San Diego Tesler Glenn 47 Pevzner Pavel A. 48, University of California, Santa Cruz Haussler David 49 Roskin Krishna M. 50 Baertsch Robert 50 Clawson Hiram 50 Furey Terrence S. 50 Hinrichs Angie S. 50 Karolchik Donna 50 Kent William J. 50 Rosenbloom Kate R. 50 Trumbower Heather 50 Weirauch Matt 36 50, University of Wales College of Medicine Cooper David N. 51 Stenson Peter D. 51, University of Western Ontario Ma Bin 52, Washington University Brent Michael 53 Arumugam Manimozhiyan 53 Shteynberg David 53, Wellcome Trust Centre for Human Genetics, University of Oxford Copley Richard R. 54 Taylor Martin S. 54, Wistar Institute Riethman Harold 55 Mudunuri Uma 55, Jane Peterson, Mark Guyer, Adam Felsenfeld, Susan Old, Stephen Mockrin, Francis Collins
Publication date
2004/4/1
Journal
Nature
Volume
428
Issue
6982
Pages
493-521
Publisher
Nature Publishing Group UK
Description
The laboratory rat (Rattus norvegicus) is an indispensable tool in experimental medicine and drug development, having made inestimable contributions to human health. We report here the genome sequence of the Brown Norway (BN) rat strain. The sequence represents a high-quality ‘draft’ covering over 90% of the genome. The BN rat sequence is the third complete mammalian genome to be deciphered, and three-way comparisons with the human and mouse genomes resolve details of mammalian evolution. This first comprehensive analysis includes genes and proteins and their relation to human disease, repeated sequences, comparative genome-wide studies of mammalian orthologous chromosomal regions and rearrangement breakpoints, reconstruction of ancestral karyotypes and the events leading to existing species, rates of variation, and lineage-specific and lineage-independent evolutionary events …
Total citations
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