Authors
European Bioinformatics Institute: Birney Ewan 3 Goldman Nick 3 Kasprzyk Arkadiusz 3 Mongin Emmanuel 3 Rust Alistair G. 3 Slater Guy 3 Stabenau Arne 3 Ureta-Vidal Abel 3 Whelan Simon 3, Research Group in Biomedical Informatics Abril Josep F. 5 Guigó Roderic 5 Parra Genís 5, Bioinformatics Agarwal Pankaj 6, National Center for Biotechnology Information Agarwala Richa 7 Church Deanna M. 7 Hlavina Wratko 7 Maglott Donna R. 7 Sapojnikov Victor 7, Department of Mathematics Alexandersson Marina 8 Pachter Lior 8, Division of Medical Genetics Antonarakis Stylianos E. 9 Dermitzakis Emmanouil T. 9 Reymond Alexandre 9 Ucla Catherine 9, Center for Biomolecular Science and Engineering Baertsch Robert 10 Diekhans Mark 10 Furey Terrence S. 10 Hinrichs Angela 10 Hsu Fan 10 Karolchik Donna 10 Kent W. James 10 Roskin Krishna M. 10 Schwartz Matthias S. 10 Sugnet Charles 10 Weber Ryan J. 10, EMBL Bork Peer 11 Letunic Ivica 11 Suyama Mikita 11 Torrents David 11 Zdobnov Evgeny M. 11, UK MRC Mouse Sequencing Consortium Botcherby Marc 12 Brown Stephen D. 12 Campbell Robert D. 12 Jackson Ian 12, Lawrence Berkeley National Laboratory Bray Nicolas 13 Couronne Olivier 13 Dubchak Inna 13 Poliakov Alex 13 Rubin Edward M. 13, Department of Computer Science Brent Michael R. 14 Flicek Paul 14 Keibler Evan 14 Korf Ian 14, School of Computer Science Batalov S. 15, Jackson Laboratory Bult Carol 16 Frankel Wayne N. 16, Laboratory for Genome Exploration Carninci Piero 17 Hayashizaki Yoshihide 17 Kawai Jun 17 Okazaki Yasushi 17, Affymetrix Inc. Cawley Simon 18 Kulp David 18 Wheeler Raymond 18, Departments of Statistics and Health Evaluation Sciences Chiaromonte Francesca 19, National Human Genome Research Institute Collins Francis S. 20 Felsenfeld Adam 20 Guyer Mark 20 Peterson Jane 20 Wetterstrand Kris 20, Wellcome Trust Centre for Human Genetics Copley Richard R. 21 Mott Richard 21, Department of Electrical Engineering Dewey Colin 22, Department of Human Anatomy and Genetics Dickens Nicholas J. 23 Emes Richard D. 23 Goodstadt Leo 23 Ponting Chris P. 23 Winter Eitan 23, Department of Human Genetics Dunn Diane M. 24 von Niederhausern Andrew C. 24 Weiss Robert B. 24, Howard Hughes Medical Institute and Department of Genetics Eddy Sean R. 25 Johnson L. Steven 25 Jones Thomas A. 25, Departments of Biochemistry and Molecular Biology and Computer Science and Engineering Elnitski Laura 26 Kolbe Diana L. 26, Department of Computer Science and Engineering Eswara Pallavi 27 Miller Webb 27 O'Connor Michael J. 27 Schwartz Scott 27, Baylor College of Medicine Gibbs Richard A. 28 Muzny Donna M. 28, Institute for Systems Biology Glusman Gustavo 29 Smit Arian 29, National Human Genome Research Institute Green Eric D. 30, Department of Biochemistry and Molecular Biology Hardison Ross C. 31 Yang Shan 31, Howard Hughes Medical Institute Haussler David 32, Department of Chemistry and Biochemistry Hua Axin 33 Roe Bruce A. 33, Departments of Genetics and Medicine and Harvard-Partners Center for Genetics and Genomics Kucherlapati Raju S. 34 Montgomery Kate T. 34, Department of Statistics Li Jia 35, Department of Computer Science Li Ming 36, US DOE Joint Genome Institute Lucas Susan 37, Department of Computer Science Ma Bin 38, Cold Spring Harbor Laboratory McCombie W. Richard 39, Wellcome Trust Morgan Michael 40, Department of Computer Science and Engineering Pevzner Pavel 41 Tesler Glenn 41, Max Planck Institute for Molecular Genetics Schultz Jörg 42, Genome Therapeutics Corporation Smith Douglas R. 43, Bioinformatics Solutions Inc. Tromp John 44, Department of Molecular and Human Genetics Worley Kim C. 45, Department of Biology Lander Eric S. lander@ genome. wi. mit. edu 2 46 b
Publication date
2002/12/5
Journal
Nature
Volume
420
Issue
6915
Pages
520-562
Publisher
Nature Publishing Group UK
Description
The sequence of the mouse genome is a key informational tool for understanding the contents of the human genome and a key experimental tool for biomedical research. Here, we report the results of an international collaboration to produce a high-quality draft sequence of the mouse genome. We also present an initial comparative analysis of the mouse and human genomes, describing some of the insights that can be gleaned from the two sequences. We discuss topics including the analysis of the evolutionary forces shaping the size, structure and sequence of the genomes; the conservation of large-scale synteny across most of the genomes; the much lower extent of sequence orthology covering less than half of the genomes; the proportions of the genomes under selection; the number of protein-coding genes; the expansion of gene families related to reproduction and immunity; the evolution of proteins; and the …
Total citations
Scholar articles
European Bioinformatics Institute: Birney Ewan 3 … - Nature, 2002
