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Biodegradable polymers represent a class of extremely useful materials for many biomedical and pharmaceutical applications, as exemplified by drug delivery systems, which in recent years have taken advantage of (bio)degradable polymeric matrices. However, before being selected for any biomedical application, a biodegradable polymer requires careful investigation of its interactions and compatibility within the human body. To date, polyesters, both natural and synthetic, constitute the most fully developed class of degradable biomaterials. Poly(ε-caprolactone) (PCL) and polylactides (PLAs), recognized as biocompatible and biodegradable polyesters, are very promising for controlled drug delivery devices. Bacterial polyesters and malic acid-based polymers (poly(malic acid), PMLA and derivatives) are poly(β-hydroxyacid)-type polyesters that represent excellent alternatives for temporary therapeutic …