Authors
L‐L Bu, F‐T Liu, C‐F Jiang, S‐S Guo, H Yu, C‐T Zuo, P Wu, J Wang
Publication date
2018/8
Journal
Acta Neurologica Scandinavica
Volume
138
Issue
2
Pages
170-176
Description
Objectives
To investigate the differences in the pattern of striatal (caudate and putamen) dopamine transporter (DAT) loss in a multiple system atrophy (MSA) cohort, based on the clinical variants parkinsonian subtype (MSA‐P) and cerebellar subtype (MSA‐C) via (11)C‐N‐2‐carbomethoxy‐3‐(4‐fluorophenyl)‐tropane (11C‐CFT) positron emission tomography (PET) imaging.
Materials and Methods
One hundred and six subjects (forty‐one patients with probable MSA‐P; forty patients with probable MSA‐C; twenty‐five healthy controls) underwent 11C‐CFT PET. Subregional 11C‐CFT uptake of bilateral caudate, anterior putamen, and posterior putamen was calculated respectively to measure the striatal dopaminergic function.
Results
Significant decrease in DAT binding in striatum was revealed in patients with MSA‐C and MSA‐P compared to normal controls (all regions, MSA‐C vs controls, P < .0001; MSA‐P vs …
Scholar articles
LL Bu, FT Liu, CF Jiang, SS Guo, H Yu, CT Zuo, P Wu… - Acta Neurologica Scandinavica, 2018