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1Biophysics PhD Program, Stanford University, Stanford, CA, USA, 2Department of Microbiology and Immunology, Stanford University, Stanford, CA, USA, 3Division of CryoEM and Bioimaging, Stanford Synchrotron Radiation Lightsource, Stanford Linear Accelerator Center National Accelerator Laboratory, Menlo Park, CA, USA, 4Department of Chemistry, Stanford University, Stanford, CA, USA. Approximately 1 billion people globally are infected by the parasite Toxoplasma gondii. While most infections are asymptomatic, serious disease can occur in the immunocompromised and in fetuses. Despite the organism’s significance to human health, there are many gaps in our understanding of its basic biology. The parasite uses an apical complex (AC) comprised of secretory organelles and proteinaceous structures to drive invasion of virtually any animal cell. However, fundamental details of AC organization and …