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We formalize a new cryptographic primitive that we call Message-Locked Encryption (MLE), where the key under which encryption and decryption are performed is itself derived from the message. MLE provides a way to achieve secure deduplication (space-efficient secure outsourced storage), a goal currently targeted by numerous cloudstorage providers. We provide definitions both for privacy and for a form of integrity that we call tag consistency. Based on this foundation, we make both practical and theoretical contributions. On the practical side, we provide ROM security analyses of a natural family of MLE schemes that includes deployed schemes. On the theoretical side the challenge is standard model solutions, and we make connections with deterministic encryption, hash functions secure on correlated inputs and the sample-then-extract paradigm to deliver schemes under different assumptions and for …